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Advances and Challenges of CAR T Cells in Clinical Trials.

Holzinger, Astrid; Abken, Hinrich.
Recent Results Cancer Res; 214: 93-128, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31473850
As a specifically programmable, living immunotherapeutic drug, chimeric antigen receptor (CAR)-modified T cells are providing an alternative treatment option for a broad variety of diseases including so far refractory cancer. By recognizing a tumor-associated antigen, the CAR triggers an anti-tumor response of engineered patient's T cells achieving lasting remissions in the treatment of leukemia and lymphoma. During the last years, significant progress was made in optimizing the CAR design, in manufacturing CAR-engineered T cells, and in the clinical management of patients showing promise to establish adoptive CAR T cell therapy as an effective treatment option in the forefront.
Selo DaSilva