A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma.
Diagn Pathol
; 14(1): 100, 2019 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-31484540
ABSTRACT
BACKGROUND:
To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL).METHODS:
LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration.RESULTS:
The sensitivity and specificity of LMO2 negative for detecting BL were 98.67 and 100%, respectively; those of CD38 positive were 98.67 and 66.67%, respectively. The sensitivity and specificity of a combination of both for detecting BL were 97.33 and 100%, respectively. In our study, the combined LMO2 negative and CD38 positive results had a higher area under the curve than either LMO2 negative or CD38 positive alone.CONCLUSIONS:
A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
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Biomarcadores Tumorais
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Proteínas Proto-Oncogênicas
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Linfoma de Burkitt
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Proteínas Adaptadoras de Transdução de Sinal
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ADP-Ribosil Ciclase 1
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Proteínas com Domínio LIM
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Diagn Pathol
Ano de publicação:
2019
Tipo de documento:
Article