Relationships between endogenous CYP3A markers and plasma amlodipine exposure and metabolism in early postpartum and non-peripartum women with hypertension.
Pregnancy Hypertens
; 17: 209-215, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-31487643
ABSTRACT
OBJECTIVE:
This study aimed to evaluate the relationship between endogenous CYP3A markers and plasma amlodipine (AML) exposure and metabolism parameters in early postpartum and non-peripartum women.METHODS:
Twenty-four AML-treated early postpartum women with hypertensive disorders of pregnancy and 30 non-peripartum women with essential hypertension were enrolled. Blood samples for determination of CYP3A markers including total cholesterol-adjusted 4ß-hydroxycholesterol (4ß-OHC/TC), 25-hydroxyvitamin D (25-OHD), and AML and its metabolites in plasma were collected at 24â¯h after the AML treatment.RESULTS:
The plasma 4ß-OHC/TC in postpartum women was higher than that in non-peripartum women, while the plasma 25-OHD was lower. The postpartum women had a lower plasma AML concentration and its metabolic ratio was higher. The plasma 4ß-OHC/TC decreased as the number of days post-delivery increased. The plasma AML concentration increased as the number of days post-delivery increased, while the metabolic ratio of AML declined slightly. Tendency toward negative correlations between the plasma 4ß-OHC/TC but not 25-OHD, and AML concentration were observed in both postpartum and non-peripartum women. In both groups, the plasma 4ß-OHC/TC was correlated with the metabolic ratio of AML.CONCLUSIONS:
The early postpartum women had higher plasma 4ß-OHC and AML metabolism. The plasma 4ß-OHC had positive relationships with amlodipine metabolism in both women groups. AML metabolism and plasma 4ß-OHC may be useful as CYP3A markers in early postpartum and non-peripartum women.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
5_ODS3_mortalidade_materna
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Complicações Cardiovasculares na Gravidez
/
Anlodipino
/
Citocromo P-450 CYP3A
/
Hipertensão
/
Anti-Hipertensivos
Tipo de estudo:
Observational_studies
Limite:
Adult
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Aged
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Aged80
/
Female
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Humans
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Middle aged
/
Pregnancy
Idioma:
En
Revista:
Pregnancy Hypertens
Ano de publicação:
2019
Tipo de documento:
Article