Development and application of a rapid and sensitive LC-MS/MS method for simultaneous quantification of six diterpene lactones in rats after oral administration of Rhizoma Dioscoreae Bulbiferae extract.

Fu, Shujun; Du, Lemei; Wu, Zengguang; Hu, Peng; Huang, Cong; Zhang, Shouqing; He, Xin

Fu, Shujun; Du, Lemei; Wu, Zengguang; Hu, Peng; Huang, Cong; Zhang, Shouqing; He, Xin.

Afiliação

Fu S; Tianjin University of Traditional Chinese Medicine, School of Chinese Materia Medica, Jinghai District, Tianjin 301617, PR China; Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, PR China.
Du L; Tianjin University of Traditional Chinese Medicine, School of Chinese Materia Medica, Jinghai District, Tianjin 301617, PR China.
Wu Z; Tianjin University of Traditional Chinese Medicine, School of Chinese Materia Medica, Jinghai District, Tianjin 301617, PR China.
Hu P; Tianjin University of Traditional Chinese Medicine, School of Chinese Materia Medica, Jinghai District, Tianjin 301617, PR China.
Huang C; Tianjin University of Traditional Chinese Medicine, School of Chinese Materia Medica, Jinghai District, Tianjin 301617, PR China.
Zhang S; Tianjin International Joint Academy of Biomedicine, Tianjin 300457, PR China.
He X; Tianjin University of Traditional Chinese Medicine, School of Chinese Materia Medica, Jinghai District, Tianjin 301617, PR China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 301617, PR China. Electronic address: hexintn@163.com.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1128: 121781, 2019 Oct 01.

Article em En | MEDLINE | ID: mdl-31520947

Assuntos

Dioscorea; Diterpenos/sangue; Diterpenos/farmacocinética; Lactonas/sangue; Lactonas/farmacocinética; Administração Oral; Animais; Cromatografia Líquida/métodos; Diterpenos/química; Lactonas/química; Modelos Lineares; Masculino; Extratos Vegetais/administração & dosagem; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes; Sensibilidade e Especificidade; Espectrometria de Massas em Tandem/métodos

Palavras-chave

Diterpene lactones; LC-MS/MS; Pharmacokinetics; Rat plasma; Rhizoma Dioscoreae Bulbiferae

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dioscorea / Diterpenos / Lactonas Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Ano de publicação: 2019 Tipo de documento: Article

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