Peripheral CD19+CD24highCD38high B-regulatory cells in lung transplant recipients.
Transpl Immunol
; 57: 101245, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31526864
ABSTRACT
BACKGROUND:
The role of CD19+CD24highCD38high B-regulatory cells in solid-organ Transplant (Tx) in acceptance are still scarce. In previous studies on kidney transplant recipients may suggest a protective role of this cell subtype in graft tolerance and the existence of a cross talk between B-and T-regulatory clones. In lung transplantation, the role of B-regulatory cells has never been investigated. In a murine tracheal transplantation model, this subset seems able to prevent tracheal obliteration when in combination with rapamycin. Aim of this study is to analyze peripheral CD19+CD24highCD38high B-reg cells counts in a cohort of lung recipients, their association with several clinical and pharmacological variables and their possible association with T regulatory cell.METHODS:
From Jan 2009 to Dec 2014, 117 lung Tx recipients were submitted to an immunological follow up I-FU(median 108.7â¯months (6.7-310.5)). Immunological follow up consisted of a complete blood peripheral immuno-phenotype, inclusive of CD19+CD24highCD38high B-cells (globally 1106 determinations). We tested the association between B-reg and relevant variables by linear or regression models for repeated measures, adjusting for time from Tx.RESULTS:
Among all variables analyzed at multivariateanalysis:
chronic rejection (ORâ¯-â¯0.19, pâ¯=â¯.039), use of Mycophenolate (ORâ¯-â¯0.38, pâ¯<â¯.001) and the presence of a concomitant pulmonary infection of S. aureus (OR 0.66, pâ¯=â¯.002) and A. fumigatus (OR 0.50, pâ¯=â¯.009) were significantly associated to B-reg cell. No significant correlation between CD19+CD24highCD38high B-reg cells and T-reg cells counts was found in our cohort.CONCLUSIONS:
Our present data highlight, for the first time, that this cell subset might participate in long-term lung graft acceptance mechanisms.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aspergillus fumigatus
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Infecções Respiratórias
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Infecções Estafilocócicas
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Staphylococcus aureus
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Transplante de Pulmão
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Linfócitos T Reguladores
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Aspergilose Pulmonar
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Linfócitos B Reguladores
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Rejeição de Enxerto
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Transpl Immunol
Ano de publicação:
2019
Tipo de documento:
Article