Hypoxia-induced biosynthesis of gold nanoparticles in the living brain.
Nanoscale
; 11(41): 19285-19290, 2019 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-31539009
ABSTRACT
While a large number of studies deal with biomedical applications of various types of nanoparticles synthesized using wet chemistry, we propose the concept of targeted biosynthesis of nanoparticles in the living brain. Here we demonstrate that the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious conditions of brain hypoxia can be redirected to drive the biosynthesis of biocompatible Au nanoparticles from a precursor salt in situ in the immediate vicinity of the hypoxia site, thereby restoring the redox status of the brain.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Hipóxia Celular
/
Nanopartículas Metálicas
/
Ouro
Limite:
Animals
Idioma:
En
Revista:
Nanoscale
Ano de publicação:
2019
Tipo de documento:
Article