Therapeutic Drug Monitoring of Biologics During Induction to Prevent Primary Non-Response.
J Crohns Colitis
; 14(4): 542-556, 2020 May 21.
Article
em En
| MEDLINE
| ID: mdl-31549158
ABSTRACT
Biologic therapies have revolutionized the management of inflammatory bowel disease [IBD], but primary and secondary non-responses occur in a significant proportion of patients. Therapeutic drug monitoring [TDM] now has an established role in the treatment algorithm for managing secondary loss of response to anti-tumour necrosis factor [anti-TNF] agents during maintenance therapy. Data to support the use of TDM in the management of secondary loss of response to vedolizumab and ustekinumab are emerging. The potential to prevent primary non-response to biologic agents during induction is of equal, and potentially greater, clinical importance. Again, most data supporting the use of 'proactive' TDM during induction pertains to the use of anti-TNF agents, but signals of efficacy for the use of TDM during induction with other biologic classes are now appearing. This review aims to summarize data on the use of TDM during induction to prevent pharmacokinetic primary non-response to all three classes of biologic therapy currently available for the treatment of IBD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
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Indução de Remissão
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Doenças Inflamatórias Intestinais
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Monitoramento de Medicamentos
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Biomarcadores Farmacológicos
Limite:
Humans
Idioma:
En
Revista:
J Crohns Colitis
Ano de publicação:
2020
Tipo de documento:
Article