Discovery of diverse diterpenoid scaffolds from Euphorbia antiquorum and their activity against RANKL-induced osteoclastogenesis.

Yin, Zhi-Yong; Dai, Yan; Hua, Pei; Sun, Zhe-Jun; Cheng, Yan-Fang; Yuan, Sheng-Heng; Chen, Zi-Yang; Gu, Qiong

Yin, Zhi-Yong; Dai, Yan; Hua, Pei; Sun, Zhe-Jun; Cheng, Yan-Fang; Yuan, Sheng-Heng; Chen, Zi-Yang; Gu, Qiong.

Afiliação

Yin ZY; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Dai Y; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Hua P; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Sun ZJ; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Cheng YF; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Yuan SH; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Chen ZY; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Gu Q; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: guqiong@mail.sysu.edu.cn.

Bioorg Chem ; 92: 103292, 2019 11.

Article em En | MEDLINE | ID: mdl-31561105

Assuntos

Diterpenos/farmacologia; Descoberta de Drogas; Euphorbia/química; Osteogênese/efeitos dos fármacos; Extratos Vegetais/farmacologia; Ligante RANK/antagonistas & inibidores; Animais; Sobrevivência Celular/efeitos dos fármacos; Células Cultivadas; Cristalografia por Raios X; Diterpenos/química; Diterpenos/isolamento & purificação; Relação Dose-Resposta a Droga; Camundongos; Camundongos Endogâmicos C57BL; Modelos Moleculares; Estrutura Molecular; Osteoclastos/efeitos dos fármacos; Extratos Vegetais/química; Extratos Vegetais/isolamento & purificação; Ligante RANK/metabolismo; Relação Estrutura-Atividade

Palavras-chave

Diterpenoids; Euphorbia antiquorum; Osteoporosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Extratos Vegetais / Euphorbia / Diterpenos / Ligante RANK / Descoberta de Drogas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Bioorg Chem Ano de publicação: 2019 Tipo de documento: Article

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