Cardiorespiratory Fitness, Lung Cancer Incidence, and Cancer Mortality in Male Smokers.
Am J Prev Med
; 57(5): 659-666, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31564605
ABSTRACT
INTRODUCTION:
The preventive role of cardiorespiratory fitness in lung cancer among smokers is unknown. This study aims to evaluate the association between cardiorespiratory fitness and lung cancer incidence and cancer mortality in former and current male smokers.METHODS:
From 1987 to 2014, cardiorespiratory fitness (quantified from treadmill exercise testing) was assessed in 2,979 men (former smokers, n=1,602; current smokers, n=1,377) aged 59.1 (SD=17.4) years and prospectively followed up for 11.6 (SD=7) years. Multivariable Cox hazard models and population attributable fraction of low cardiorespiratory fitness (<5 METs) for cancer outcomes were analyzed during 2018.RESULTS:
Of the 99 case patients diagnosed with lung cancer, 79 died of cancer 3.6 (SD=4.6) years after diagnosis. Among former smokers, 1-MET increase and categories of moderate and high cardiorespiratory fitness were associated with 13% (p=0.016), 51%, and 77% (p-trend=0.015) reductions in lung cancer incidence, respectively. Among current smokers who were later diagnosed with lung cancer, 1-MET increase and categories of moderate and high cardiorespiratory fitness were associated with 18% (p=0.008), 84%, and 85% (p-trend<0.001) reductions in cancer mortality, respectively. The population attributable fraction for lung cancer incidence was 10.8% among former smokers and 22.3% for cancer mortality among current smokers.CONCLUSIONS:
Higher cardiorespiratory fitness is associated with lower risk of lung cancer incidence in former smokers and reduced risk of cancer mortality in current smokers who were diagnosed with lung cancer. Screening for low cardiorespiratory fitness and achieving at least moderate cardiorespiratory fitness could potentially reduce lung cancer morbidity and mortality, providing a preventive strategy for smokers.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
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6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Mortalidade
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Aptidão Cardiorrespiratória
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Fumar Cigarros
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Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Humans
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Male
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Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Am J Prev Med
Ano de publicação:
2019
Tipo de documento:
Article