External validation of the electronic Frailty Index using the population of Wales within the Secure Anonymised Information Linkage Databank.
Age Ageing
; 48(6): 922-926, 2019 11 01.
Article
em En
| MEDLINE
| ID: mdl-31566668
ABSTRACT
BACKGROUND:
frailty has major implications for health and social care services internationally. The development, validation and national implementation of the electronic Frailty Index (eFI) using routine primary care data has enabled change in the care of older people living with frailty in England.AIMS:
to externally validate the eFI in Wales and assess new frailty-related outcomes. STUDY DESIGN ANDSETTING:
retrospective cohort study using the Secure Anonymised Information Linkage (SAIL) Databank, comprising 469,000 people aged 65-95, registered with a SAIL contributing general practice on 1 January 2010.METHODS:
four categories (fit; mild; moderate and severe) of frailty were constructed using recognised cut points from the eFI. We calculated adjusted hazard ratios (HRs) from Cox regression models for validation of existingoutcomes:
1-, 3- and 5-year mortality, hospitalisation, and care home admission for validation. We also analysed, as novel outcomes, 1-year mortality following hospitalisation and frailty transition times.RESULTS:
HR trends for the validation outcomes in SAIL followed the original results from ResearchOne and THIN databases. Relative to the fit category, adjusted HRs in SAIL (95% CI) for 1-year mortality following hospitalisation were 1.05 (95% CI 1.03-1.08) for mild frailty, 1.24 (95% CI 1.21-1.28) for moderate frailty and 1.51 (95% CI 1.45-1.57) for severe frailty. The median time (lower and upper quartile) between frailty categories was 2,165 days (lower and upper quartiles 1,510 and 2,831) from fit to mild, 1,155 days (lower and upper quartiles 756 and 1,610) from mild to moderate and 898 days (lower and upper quartiles 584 and 1,275) from moderate to severe.CONCLUSIONS:
further validation of the eFI showed robust predictive validity and utility for new outcomes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Fragilidade
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Age Ageing
Ano de publicação:
2019
Tipo de documento:
Article