Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats.
Drug Des Devel Ther
; 13: 3357-3367, 2019.
Article
em En
| MEDLINE
| ID: mdl-31576110
ABSTRACT
BACKGROUND:
Histamine H1 receptor antagonists are widely used in the treatment of allergic diseases. H1 receptors are expressed on bone cells and histamine takes part in regulation of bone metabolism. Loratadine is often prescribed to children.PURPOSE:
The aim of the present study was to investigate the effects of loratadine on the skeletal system of young rats. MATERIAL ANDMETHODS:
Loratadine (0.5, 5, and 50 mg/kg p.o. daily) was administered for 4 weeks to male Wistar rats, 6-week-old at the start of the experiment. Bone mass, mass of bone mineral, calcium, and phosphorus content in the bone mineral of the tibia, femur, and L-4 vertebra, histomorphometric parameters of the femur, mechanical properties of the proximal tibial metaphysis, femoral diaphysis and femoral neck, and serum levels of bone turnover markers were examined.RESULTS:
Loratadine at 0.5 and 5 mg/kg did not significantly affect the skeletal system of young rats. At 50 mg/kg, loratadine decreased the femoral length, increased content of calcium and phosphorus in the bone mineral of the vertebra, and tended to improve mechanical properties of the tibial metaphysis.CONCLUSION:
High-dose loratadine slightly but significantly affected development of the skeletal system in rapidly growing rats.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osso e Ossos
/
Loratadina
/
Antagonistas dos Receptores Histamínicos H1
/
Sistema Musculoesquelético
Limite:
Animals
Idioma:
En
Revista:
Drug Des Devel Ther
Ano de publicação:
2019
Tipo de documento:
Article