ERp29 inhibition attenuates TCA toxicity via affecting p38/p53- dependent pathway in human trophoblast HTR-8/SVeno cells.

Zou, Shaohan; Zou, Ping; Wang, Yao; Dong, Ruirui; Wang, Jing; Li, Na; Wang, Tiejun; Zhou, Tao; Chen, Zhong; Zhang, Yan; Chen, Minjian; Zhou, Conghua; Zhang, Ting; Luo, Liang

Zou, Shaohan; Zou, Ping; Wang, Yao; Dong, Ruirui; Wang, Jing; Li, Na; Wang, Tiejun; Zhou, Tao; Chen, Zhong; Zhang, Yan; Chen, Minjian; Zhou, Conghua; Zhang, Ting; Luo, Liang.

Afiliação

Zou S; Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China.
Zou P; The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China.
Wang Y; The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China.
Dong R; The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China.
Wang J; The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China.
Li N; The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China.
Wang T; The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China.
Zhou T; The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China.
Chen Z; The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China.
Zhang Y; The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China.
Chen M; State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, J
Zhou C; School of Computer Science and Telecommunication Engineering, Jiangsu University, Zhenjiang, 212013, Jiangsu Province, China.
Zhang T; The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China. Electronic address: zhangting040715@outlook.com.
Luo L; The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu Province, China. Electronic address: luoliang0916@163.com.

Arch Biochem Biophys ; 676: 108125, 2019 11 15.

Article em En | MEDLINE | ID: mdl-31586554

Assuntos

Técnicas de Silenciamento de Genes; Proteínas de Choque Térmico/genética; Ácido Taurocólico/toxicidade; Trofoblastos/citologia; Trofoblastos/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo; Apoptose/efeitos dos fármacos; Apoptose/genética; Linhagem Celular; Colestase Intra-Hepática/genética; Colestase Intra-Hepática/metabolismo; Colestase Intra-Hepática/patologia; Feminino; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos; Pontos de Checagem da Fase G2 do Ciclo Celular/genética; Proteínas de Choque Térmico/deficiência; Humanos; Pontos de Checagem da Fase M do Ciclo Celular/efeitos dos fármacos; Pontos de Checagem da Fase M do Ciclo Celular/genética; Fosforilação/efeitos dos fármacos; Fosforilação/genética; Gravidez; Complicações na Gravidez/genética; Complicações na Gravidez/metabolismo; Complicações na Gravidez/patologia; Trofoblastos/efeitos dos fármacos

Palavras-chave

Endoplasmic reticulum protein 29; Intrahepatic cholestasis of pregnancy; p38/p53-dependent pathway

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Ácido Taurocólico / Trofoblastos / Proteína Supressora de Tumor p53 / Proteínas Quinases p38 Ativadas por Mitógeno / Técnicas de Silenciamento de Genes / Proteínas de Choque Térmico Limite: Female / Humans / Pregnancy Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2019 Tipo de documento: Article

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