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Health outcomes, utility and costs of returning incidental results from genomic sequencing in a Canadian cancer population: protocol for a mixed-methods randomised controlled trial.
Shickh, Salma; Clausen, Marc; Mighton, Chloe; Gutierrez Salazar, Mariana; Zakoor, Kathleen-Rose; Kodida, Rita; Reble, Emma; Elser, Christine; Eisen, Andrea; Panchal, Seema; Aronson, Melyssa; Graham, Tracy; Armel, Susan Randall; Morel, Chantal F; Fattouh, Ramzi; Glogowski, Emily; Schrader, Kasmintan A; Hamilton, Jada G; Offit, Kenneth; Robson, Mark; Carroll, June C; Isaranuwatchai, Wanrudee; Kim, Raymond H; Lerner-Ellis, Jordan; Thorpe, Kevin E; Laupacis, Andreas; Bombard, Yvonne.
Afiliação
  • Shickh S; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
  • Clausen M; Genomics Health Services Research Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Mighton C; Genomics Health Services Research Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Gutierrez Salazar M; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
  • Zakoor KR; Genomics Health Services Research Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Kodida R; Genomics Health Services Research Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Reble E; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.
  • Elser C; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.
  • Eisen A; Genomics Health Services Research Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Panchal S; Genomics Health Services Research Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Aronson M; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Graham T; Marvelle Koffler Breast Centre, Mount Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.
  • Armel SR; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
  • Morel CF; Marvelle Koffler Breast Centre, Mount Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.
  • Fattouh R; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.
  • Glogowski E; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
  • Schrader KA; Familial Breast Ovarian Cancer Clinic, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Hamilton JG; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Offit K; Fred A. Litwin Centre in Genetic Medicine, University Health Network, Toronto, Ontario, Canada.
  • Robson M; Department of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Carroll JC; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Isaranuwatchai W; GeneDx, Elmwood Park, New Jersey, USA.
  • Kim RH; Department of Molecular Oncology and Hereditary Cancer Program, BC Cancer Agency, Vancouver, British Columbia, Canada.
  • Lerner-Ellis J; Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.
  • Thorpe KE; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.
  • Laupacis A; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.
  • Bombard Y; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.
BMJ Open ; 9(10): e031092, 2019 10 07.
Article em En | MEDLINE | ID: mdl-31594892
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Padrões de Prática Médica / Análise de Sequência de DNA / Achados Incidentais Tipo de estudo: Clinical_trials / Diagnostic_studies / Evaluation_studies / Health_economic_evaluation / Prognostic_studies / Qualitative_research Aspecto: Ethics / Patient_preference Limite: Adult / Female / Humans / Male Idioma: En Revista: BMJ Open Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Padrões de Prática Médica / Análise de Sequência de DNA / Achados Incidentais Tipo de estudo: Clinical_trials / Diagnostic_studies / Evaluation_studies / Health_economic_evaluation / Prognostic_studies / Qualitative_research Aspecto: Ethics / Patient_preference Limite: Adult / Female / Humans / Male Idioma: En Revista: BMJ Open Ano de publicação: 2019 Tipo de documento: Article