Quantifying fetal alcohol exposure by meconium fatty acid ethyl esters (FAEE); association with adverse fetal outcomes and population estimates of fetal alcohol exposure.
Drug Metab Rev
; 51(4): 524-532, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31595802
ABSTRACT
Fetal Alcohol Spectrum Disorder (FASD) describes the wide range of adverse physical, behavioral and cognitive effects resulting from ethanol exposure during embryonic and fetal development. Identification of children suffering from FASD is often difficult, as abuse of ethanol during pregnancy is a heavily stigmatized behavior that receives little prenatal screening attention in routine care. Over the last 3 decades, measurement of the ethanol metabolites fatty acid ethyl esters (FAEE) has emerged as a useful tool to detect in the neonatal period fetal alcohol exposure starting from mid gestation. This review aims at updating clinicians and researchers on the validity and utility of this biological marker in two aspects The association with adverse fetal outcomes and in generating population estimates of fetal alcohol exposure.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
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Consumo de Bebidas Alcoólicas
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Ácidos Graxos
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Transtornos do Espectro Alcoólico Fetal
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Mecônio
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Animals
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Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Drug Metab Rev
Ano de publicação:
2019
Tipo de documento:
Article