Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18.

Jergovic, Mladen; Thompson, Heather L; Renkema, Kristin R; Smithey, Megan J; Nikolich-Zugich, Janko

Jergovic, Mladen; Thompson, Heather L; Renkema, Kristin R; Smithey, Megan J; Nikolich-Zugich, Janko.

Afiliação

Jergovic M; Department of Immunobiology and the University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ, United States.
Thompson HL; Department of Immunobiology and the University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ, United States.
Renkema KR; Department of Immunobiology and the University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ, United States.
Smithey MJ; Biomedical Sciences Department, Grand Valley State University, Allendale, MI, United States.
Nikolich-Zugich J; Department of Immunobiology and the University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ, United States.

Front Immunol ; 10: 2206, 2019.

Article em En | MEDLINE | ID: mdl-31620129

Assuntos

Envelhecimento/imunologia; Interleucina-12/imunologia; Interleucina-18/imunologia; Ativação Linfocitária/imunologia; Linfócitos T Citotóxicos/imunologia; Animais; Diferenciação Celular/imunologia; Listeriose/imunologia; Camundongos; Camundongos Transgênicos; Transcrição Gênica

Palavras-chave

aging; bacterial infection; cytokines; cytotoxic T cells; inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Ativação Linfocitária / Linfócitos T Citotóxicos / Interleucina-12 / Interleucina-18 Limite: Animals Idioma: En Revista: Front Immunol Ano de publicação: 2019 Tipo de documento: Article

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