Boosting Antitumour Immunity through Targeted Delivery of Interferon-&#945;.

Fairchild, Paul J; Davies, Timothy J

Boosting Antitumour Immunity through Targeted Delivery of Interferon-α.

Fairchild, Paul J; Davies, Timothy J.

Afiliação

Fairchild PJ; University of Oxford, Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK. Electronic address: Paul.Fairchild@path.ox.ac.uk.
Davies TJ; University of Oxford, Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK.

Trends Mol Med ; 25(11): 935-937, 2019 11.

Article em En | MEDLINE | ID: mdl-31624020

ABSTRACT

ABSTRACT

Immune checkpoint inhibitors (ICIs) have revolutionised cancer immunotherapy but their success is wholly dependent on amplifying an existing immune response directed against the tumour. A recent study by Tsuchiya et al. suggests how the properties of induced pluripotent stem cells (iPSCs) may be exploited for the targeted delivery of interferon-α (IFNα) to elicit an appropriate response.

Assuntos

Imunoterapia; Interferon-alfa; Terapia de Alvo Molecular; Neoplasias/imunologia; Humanos; Interferon-alfa/metabolismo; Interferon-alfa/farmacologia; Neoplasias/terapia; Células-Tronco Pluripotentes/imunologia; Células-Tronco Pluripotentes/metabolismo

Palavras-chave

dendritic cell; immune checkpoint inhibitors; interferon-α

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon-alfa / Terapia de Alvo Molecular / Imunoterapia / Neoplasias Limite: Humans Idioma: En Revista: Trends Mol Med Ano de publicação: 2019 Tipo de documento: Article

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