Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy.

Cheung, Chantal Hoi Yin; Hsu, Chia-Lang; Tsuei, Chao-Yin; Kuo, Tzu-Ting; Huang, Chen-Tsung; Hsu, Wen-Ming; Chung, Yun-Hsien; Wu, Hsin-Yi; Hsu, Cheng-Chih; Huang, Hsuan-Cheng; Juan, Hsueh-Fen

Cheung, Chantal Hoi Yin; Hsu, Chia-Lang; Tsuei, Chao-Yin; Kuo, Tzu-Ting; Huang, Chen-Tsung; Hsu, Wen-Ming; Chung, Yun-Hsien; Wu, Hsin-Yi; Hsu, Cheng-Chih; Huang, Hsuan-Cheng; Juan, Hsueh-Fen.

Afiliação

Cheung CHY; Department of Life Science, National Taiwan University, Taipei, 10617, Taiwan.
Hsu CL; Department of Life Science, National Taiwan University, Taipei, 10617, Taiwan.
Tsuei CY; Department of Medical Research, National Taiwan University Hospital, Taipei, 10002, Taiwan.
Kuo TT; Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, 10617, Taiwan.
Huang CT; Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, 10617, Taiwan.
Hsu WM; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 10617, Taiwan.
Chung YH; Department of Surgery, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, 10017, Taiwan.
Wu HY; Department of Life Science, National Taiwan University, Taipei, 10617, Taiwan.
Hsu CC; Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Huang HC; Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Juan HF; Institute of Biomedical Informatics, National Yang-Ming University, Taipei, 11221, Taiwan. hsuancheng@ym.edu.tw.

Cell Death Dis ; 10(11): 786, 2019 10 17.

Article em En | MEDLINE | ID: mdl-31624245

Assuntos

Aminoidrolases/metabolismo; Carboxiliases/metabolismo; Metilenotetra-Hidrofolato Desidrogenase (NADP)/metabolismo; Enzimas Multifuncionais/metabolismo; Purinas/biossíntese; Aminoidrolases/genética; Carboxiliases/genética; Ciclo Celular/fisiologia; Processos de Crescimento Celular; Linhagem Celular Tumoral; Técnicas de Silenciamento de Genes; Humanos; Metabolômica; Metilenotetra-Hidrofolato Desidrogenase (NADP)/genética; Terapia de Alvo Molecular; Enzimas Multifuncionais/genética; Neuroblastoma/genética; Neuroblastoma/metabolismo; Neuroblastoma/patologia; Neuroblastoma/terapia; Transcriptoma; Transfecção; Regulação para Cima

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Carboxiliases / Enzimas Multifuncionais / Aminoidrolases / Metilenotetra-Hidrofolato Desidrogenase (NADP) Limite: Humans Idioma: En Revista: Cell Death Dis Ano de publicação: 2019 Tipo de documento: Article

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