Leukocyte-specific siRNA delivery revealing IRF8 as a potential anti-inflammatory target.

Veiga, Nuphar; Goldsmith, Meir; Diesendruck, Yael; Ramishetti, Srinivas; Rosenblum, Daniel; Elinav, Eran; Behlke, Mark A; Benhar, Itai; Peer, Dan

Veiga, Nuphar; Goldsmith, Meir; Diesendruck, Yael; Ramishetti, Srinivas; Rosenblum, Daniel; Elinav, Eran; Behlke, Mark A; Benhar, Itai; Peer, Dan.

Afiliação

Veiga N; Laboratory of Precision NanoMedicine, Tel Aviv, 69978, Israel; School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv, 69978, Israel; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv, 69978, Is
Goldsmith M; Laboratory of Precision NanoMedicine, Tel Aviv, 69978, Israel; School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv, 69978, Israel; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv, 69978, Is
Diesendruck Y; School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv, 69978, Israel.
Ramishetti S; Laboratory of Precision NanoMedicine, Tel Aviv, 69978, Israel; School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv, 69978, Israel; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv, 69978, Is
Rosenblum D; Laboratory of Precision NanoMedicine, Tel Aviv, 69978, Israel; School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv, 69978, Israel; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv, 69978, Is
Elinav E; Immunology Department, Weizmann Institute of Science, Rehovot, Israel.
Behlke MA; Integrated DNA Technologies, Inc., Coralville, IA, 52241, USA.
Benhar I; School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv, 69978, Israel.
Peer D; Laboratory of Precision NanoMedicine, Tel Aviv, 69978, Israel; School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv, 69978, Israel; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv, 69978, Is

J Control Release ; 313: 33-41, 2019 11 10.

Article em En | MEDLINE | ID: mdl-31634546

Assuntos

Anti-Inflamatórios/metabolismo; Doenças Inflamatórias Intestinais/terapia; Fatores Reguladores de Interferon/genética; Leucócitos/metabolismo; Lipídeos/química; Nanopartículas/química; RNA Interferente Pequeno/metabolismo; Animais; Anticorpos/química; Anticorpos/metabolismo; Colesterol/química; Modelos Animais de Doenças; Feminino; Terapia Genética; Humanos; Imunomodulação; Fatores Reguladores de Interferon/metabolismo; Interleucinas/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Fosfatidiletanolaminas/química; Polietilenoglicóis/química; Células RAW 264.7; Propriedades de Superfície; Transfecção; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

IBD; IRF8; Immunomodulation; LNP; Nanoparticle; RNAi

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / RNA Interferente Pequeno / Fatores Reguladores de Interferon / Nanopartículas / Leucócitos / Lipídeos / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Control Release Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google