Glucocerebrosidase activity, cathepsin D and monomeric &#945;-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation.

Yang, Shi-Yu; Gegg, Matthew; Chau, David; Schapira, Anthony

Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation.

Yang, Shi-Yu; Gegg, Matthew; Chau, David; Schapira, Anthony.

Afiliação

Yang SY; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Gegg M; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Chau D; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Schapira A; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK. Electronic address: a.schapira@ucl.ac.uk.

Neurobiol Dis ; 134: 104620, 2020 02.

Article em En | MEDLINE | ID: mdl-31634558

Assuntos

Catepsina D/metabolismo; Neurônios Dopaminérgicos/metabolismo; Glucosilceramidase/metabolismo; Doença de Parkinson; alfa-Sinucleína/metabolismo; Células Cultivadas; Glucosilceramidase/genética; Humanos; Mutação; Crista Neural; Células-Tronco Neurais; Doença de Parkinson/metabolismo; Doença de Parkinson/patologia

Palavras-chave

Ambroxol; Cathepsin D; Cerezyme; Glucocerebrosidase; Monomeric α-Synuclein; Parkinson's disease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Catepsina D / Alfa-Sinucleína / Neurônios Dopaminérgicos / Glucosilceramidase Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Neurobiol Dis Ano de publicação: 2020 Tipo de documento: Article

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