NSE & S100B protein blood level assessment during a long-distance trail race.
Ann Biol Clin (Paris)
; 77(5): 532-536, 2019 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-31638583
ABSTRACT
The acute and chronic consequences of long-distance running on brain function have received little attention. The impact of such a hard-physical burden associated with sleep privation during such events such has never been explored in terms of neuropsychological function and brain damage. METHODS:
Blood samples were collected from 4 athletes before, during and at the end of one of two races Grand Raid de la Réunion 2017 (GRR 165 km, elevation gain 9529 m, 2 runners) and Trail de la Bourbon 2017 (TB 111 km, elevation gain 6433 m, 2 runners). Serum S100B and NSE levels were measured for each runner before, during and after the race.RESULTS:
Serum S100B levels (normal range < 0.15 µg/L) increased early during the race and remained high up to the end of the race in all 4 runners (range 0.17-0.59 µg/L). NSE level (normal range < 15 µg/L) increased in 3 of the 4 runners (range 16.8-39.2 µg/L).CONCLUSIONS:
This preliminary study shows the potential interest of S100B and NSE serum assessment during long-distance races. Further studies are needed to confirm these results and to investigate the origins and significance of this increase in brain injury markers.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfopiruvato Hidratase
/
Resistência Física
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Corrida
/
Biomarcadores
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Subunidade beta da Proteína Ligante de Cálcio S100
/
Montanhismo
Tipo de estudo:
Observational_studies
Aspecto:
Determinantes_sociais_saude
Limite:
Adult
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Female
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Humans
/
Male
Idioma:
En
Revista:
Ann Biol Clin (Paris)
Ano de publicação:
2019
Tipo de documento:
Article