Emerging Activators and Regulators of Inflammasomes and Pyroptosis.
Trends Immunol
; 40(11): 1035-1052, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31662274
ABSTRACT
The inflammasome is a cytosolic immune signaling complex that induces inflammation and pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger or homeostasis-altering signals; they can play critical roles in the development of autoinflammatory conditions and cancer. Studies have now provided additional insights into the activation mechanisms and regulation of established inflammasome complexes, including NLRP1b, NLRP3, NOD-like receptor family apoptosis inhibitory protein (NAIP)-NLRC4, absent in melanoma (AIM)2, caspase-11, and pyrin. New activators and regulators of emerging NLRP6 and NLRP9b inflammasome complexes have also been described. We highlight the latest progress in our understanding of the molecular mechanisms governing inflammasome activation and pyroptosis, including the discovery of the pore-forming protein gasdermin D (GSDMD). We also discuss the importance of inflammasome activators and regulators in health and disease.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inflamassomos
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Moléculas com Motivos Associados a Patógenos
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Inflamação
Limite:
Animals
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Humans
Idioma:
En
Revista:
Trends Immunol
Ano de publicação:
2019
Tipo de documento:
Article