Virescenosides From the Holothurian-Associated Fungus Acremonium Striatisporum Kmm 4401.
Mar Drugs
; 17(11)2019 Oct 29.
Article
em En
| MEDLINE
| ID: mdl-31671910
ABSTRACT
Ten new diterpene glycosides virescenosides Z9-Z18 (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassium bromide. Structures of the isolated metabolites were established based on spectroscopic methods. The effects of some isolated glycosides and aglycons 15-18 on urease activity and regulation of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) production in macrophages stimulated with lipopolysaccharide (LPC) were evaluated.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acremonium
/
Diterpenos
/
Glicosídeos
/
Macrófagos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Mar Drugs
Ano de publicação:
2019
Tipo de documento:
Article