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Virescenosides From the Holothurian-Associated Fungus Acremonium Striatisporum Kmm 4401.
Zhuravleva, Olesya I; Antonov, Alexandr S; Oleinikova, Galina K; Khudyakova, Yuliya V; Popov, Roman S; Denisenko, Vladimir A; Pislyagin, Evgeny A; Chingizova, Ekaterina A; Afiyatullov, Shamil Sh.
Afiliação
  • Zhuravleva OI; Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. zhuravleva.oi@dvfu.ru.
  • Antonov AS; Affiliation School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, 690000 Vladivostok, Russia. zhuravleva.oi@dvfu.ru.
  • Oleinikova GK; Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. pibocfebras@gmail.com.
  • Khudyakova YV; Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. oleingk@mail.ru.
  • Popov RS; Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. 161070@rambler.ru.
  • Denisenko VA; Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. prs_90@mail.ru.
  • Pislyagin EA; Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. vladenis@pidoc.dvo.ru.
  • Chingizova EA; Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. pislyagin@hotmail.com.
  • Afiyatullov SS; Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. martyyas@mail.ru.
Mar Drugs ; 17(11)2019 Oct 29.
Article em En | MEDLINE | ID: mdl-31671910
ABSTRACT
Ten new diterpene glycosides virescenosides Z9-Z18 (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassium bromide. Structures of the isolated metabolites were established based on spectroscopic methods. The effects of some isolated glycosides and aglycons 15-18 on urease activity and regulation of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) production in macrophages stimulated with lipopolysaccharide (LPC) were evaluated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acremonium / Diterpenos / Glicosídeos / Macrófagos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Mar Drugs Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acremonium / Diterpenos / Glicosídeos / Macrófagos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Mar Drugs Ano de publicação: 2019 Tipo de documento: Article