PTH/PTHrP Receptor Signaling, Allostery, and Structures.
Trends Endocrinol Metab
; 30(11): 860-874, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31699241
ABSTRACT
The parathyroid hormone (PTH) type 1 receptor (PTHR) is the canonical G protein-coupled receptor (GPCR) for PTH and PTH-related protein (PTHrP) and the key regulator of calcium homeostasis and bone turnover. PTHR function is critical for human health to maintain homeostatic control of ionized serum Ca2+ levels and has several unusual signaling features, such as endosomal cAMP signaling, that are well-studied but not structurally understood. In this review, we discuss how recently solved high resolution near-atomic structures of hormone-bound PTHR in its inactive and active signaling states and discovery of extracellular Ca2+ allosterism shed light on the structural basis for PTHR signaling and function.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Paratireóideo
/
Receptor Tipo 1 de Hormônio Paratireóideo
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Endocrinol Metab
Ano de publicação:
2019
Tipo de documento:
Article