LncRNA LINC00974 Downregulates miR-122 to Upregulate RhoA in Oral Squamous Cell Carcinoma.
Cancer Biother Radiopharm
; 36(1): 18-22, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-31702382
ABSTRACT
Background:
LncRNA LINC00974 participates in oral fibrogenesis, indicating possible involvement in other oral diseases.Results:
The authors found that LINC00974 was upregulated in oral squamous cell carcinoma (OSCC) and predicted poor survival. In OSCC tissues, LINC00974 was inversely correlated with miR-122 and positively correlated with RhoA. In OSCC cells, LINC00974 overexpression resulted in upregulated, whereas overexpression of miR-122 led to downregulated RhoA. Moreover, downregulated miR-122 was observed after LINC00974 overexpression, whereas LINC00974 expression was not significantly affected by miR-122 overexpression. In invasion and migration assay, miR-122 overexpression resulted in reduced, whereas LINC00974 and RhoA overexpression resulted in increased rate of cancer cell migration and invasion. In addition, miR-122 overexpression reduced the effects of LINC00974 overexpression.Conclusion:
Therefore, LINC00974 can downregulate miR-122 to upregulate RhoA in OSCC, thereby promoting cell invasion and migration.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
/
Proteína rhoA de Ligação ao GTP
/
MicroRNAs
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RNA Longo não Codificante
/
Carcinoma de Células Escamosas de Cabeça e Pescoço
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Cancer Biother Radiopharm
Ano de publicação:
2021
Tipo de documento:
Article