Genomic Epidemiology as a Public Health Tool to Combat Mosquito-Borne Virus Outbreaks.
J Infect Dis
; 221(Suppl 3): S308-S318, 2020 03 28.
Article
em En
| MEDLINE
| ID: mdl-31711190
ABSTRACT
Next-generation sequencing technologies, exponential increases in the availability of virus genomic data, and ongoing advances in phylogenomic methods have made genomic epidemiology an increasingly powerful tool for public health response to a range of mosquito-borne virus outbreaks. In this review, we offer a brief primer on the scope and methods of phylogenomic analyses that can answer key epidemiological questions during mosquito-borne virus public health emergencies. We then focus on case examples of outbreaks, including those caused by dengue, Zika, yellow fever, West Nile, and chikungunya viruses, to demonstrate the utility of genomic epidemiology to support the prevention and control of mosquito-borne virus threats. We extend these case studies with operational perspectives on how to best incorporate genomic epidemiology into structured surveillance and response programs for mosquito-borne virus control. Many tools for genomic epidemiology already exist, but so do technical and nontechnical challenges to advancing their use. Frameworks to support the rapid sharing of multidimensional data and increased cross-sector partnerships, networks, and collaborations can support advancement on all scales, from research and development to implementation by public health agencies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
3_ND
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4_TD
Base de dados:
MEDLINE
Assunto principal:
Controle de Mosquitos
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Saúde Pública
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Surtos de Doenças
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Genômica
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Doenças Transmitidas por Vetores
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Culicidae
Tipo de estudo:
Screening_studies
Aspecto:
Determinantes_sociais_saude
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2020
Tipo de documento:
Article