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Production of 230Pa by proton irradiation of 232Th at the LANL isotope production facility: Precursor of 230U for targeted alpha therapy.
Friend, Mitchell T; Mastren, Tara; Parker, T Gannon; Vermeulen, Christiaan E; Brugh, Mark; Birnbaum, Eva R; Nortier, F Meiring; Fassbender, Michael E.
Afiliação
  • Friend MT; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
  • Mastren T; Nuclear Engineering Program, Department of Civil and Environmental Engineering, University of Utah, 110 Central Campus Drive, Suite 2000b, Salt Lake City, UT, 84112, USA; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
  • Parker TG; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
  • Vermeulen CE; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
  • Brugh M; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
  • Birnbaum ER; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
  • Nortier FM; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
  • Fassbender ME; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA. Electronic address: mifa@lanl.gov.
Appl Radiat Isot ; 156: 108973, 2020 Feb.
Article em En | MEDLINE | ID: mdl-31727509
ABSTRACT
Uranium-230 (t1/2 = 20.8 d) is an alpha-emitting radionuclide that has potential application in targeted alpha therapy (TAT) of cancer. Its parent isotope 230Pa (t1/2 = 17.4 d), can be produced by proton irradiation of thorium metal targets. Preliminary 230Pa production runs were performed at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF) using thin thorium metal targets and a proton beam energy of 15-30 MeV, followed by radiochemical separation of 230Pa from the irradiated target matrix. The measured 230Pa production yields were found to exceed the predicted values in most of the experiments that were performed. This data will inform further production efforts for providing 230Pa/230U for clinical trials.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioisótopos / Protoactínio / Tório / Partículas alfa Idioma: En Revista: Appl Radiat Isot Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioisótopos / Protoactínio / Tório / Partículas alfa Idioma: En Revista: Appl Radiat Isot Ano de publicação: 2020 Tipo de documento: Article