Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A.
J Org Chem
; 84(24): 16323-16328, 2019 12 20.
Article
em En
| MEDLINE
| ID: mdl-31729221
ABSTRACT
Tricyclic carbazole is an important scaffold in many naturally occurring metabolites, as well as valuable building blocks. Here we report the reconstitution of the ring A formation of the bacterial neocarazostatin A carbazole metabolite. We provide evidence of the involvement of two unusual aromatic polyketide proteins. This finding suggests how new enzymatic activities can be recruited to specific pathways to expand biosynthetic capacities. Finally, we leveraged our bioinformatics survey to identify the untapped capacity of carbazole biosynthesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Transferases
/
Carbazóis
/
Sistema Enzimático do Citocromo P-450
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2019
Tipo de documento:
Article