PF4 antagonizes retinal neovascularization via inhibiting PRAS40 phosphorylation in a mouse model of oxygen-induced retinopathy.

Cai, Siwei; Yang, Qianhui; Cao, Yunshan; Li, Yahong; Liu, Juping; Wang, Jiantao; Zhang, Xiaomin; Liu, Liren; Li, Xiaorong; Zhang, Yan

Cai, Siwei; Yang, Qianhui; Cao, Yunshan; Li, Yahong; Liu, Juping; Wang, Jiantao; Zhang, Xiaomin; Liu, Liren; Li, Xiaorong; Zhang, Yan.

Afiliação

Cai S; Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
Yang Q; Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
Cao Y; Department of Cardiology, Gansu Provincial Hospital, Lanzhou University, Lanzhou, Gansu Province 730000, China.
Li Y; Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
Liu J; Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
Wang J; Shenzhen Eye Hospital, Shenzhen, Guangdong Province 518040, China.
Zhang X; Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
Liu L; Department of Gastrointestinal Cancer Biology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China. Electronic address: liuliren
Li X; Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China. Electronic address: lixiaorong@tmu.edu.cn.
Zhang Y; Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China. Electronic address: yanzhang04@tmu.edu.cn.

Biochim Biophys Acta Mol Basis Dis ; 1866(3): 165604, 2020 03 01.

Article em En | MEDLINE | ID: mdl-31740404

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/antagonistas & inibidores; Oxigênio/metabolismo; Fosfoproteínas/antagonistas & inibidores; Fator Plaquetário 4/antagonistas & inibidores; Retina/metabolismo; Neovascularização Retiniana/metabolismo; Retinopatia da Prematuridade/metabolismo; Adulto; Idoso; Idoso de 80 Anos ou mais; Animais; Modelos Animais de Doenças; Células Endoteliais/metabolismo; Feminino; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Fosforilação/fisiologia; Transdução de Sinais/fisiologia; Fator A de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

Neovascularization; Oxygen-induced retinopathy; PF4; PRAS40; Proliferative retinopathy; Retinal ischemia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Fosfoproteínas / Retina / Retinopatia da Prematuridade / Fator Plaquetário 4 / Neovascularização Retiniana / Proteínas Adaptadoras de Transdução de Sinal Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google