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5-HT2AR and BDNF gene variants in eating disorders susceptibility.
Ceccarini, M Rachele; Tasegian, Anna; Franzago, Marica; Patria, F Filomena; Albi, Elisabetta; Codini, Michela; Conte, Carmela; Bertelli, Matteo; Dalla Ragione, Laura; Stuppia, Liborio; Beccari, Tommaso.
Afiliação
  • Ceccarini MR; Department of Pharmaceutical Science, University of Perugia, Perugia, Italy.
  • Tasegian A; Department of Pharmaceutical Science, University of Perugia, Perugia, Italy.
  • Franzago M; Department of Medicine and Aging, School of Medicine and Health Sciences, "G. d'Annunzio" University, Chieti-Pescara, Italy.
  • Patria FF; Aging and Translational Medicine Research Center (CeSI-MeT), University "G. d'Annunzio", Chieti-Pescara, Italy.
  • Albi E; Department of Pharmaceutical Science, University of Perugia, Perugia, Italy.
  • Codini M; Department of Pharmaceutical Science, University of Perugia, Perugia, Italy.
  • Conte C; Department of Pharmaceutical Science, University of Perugia, Perugia, Italy.
  • Bertelli M; Department of Pharmaceutical Science, University of Perugia, Perugia, Italy.
  • Dalla Ragione L; MAGI Euregio, Non Profit Genetic Testing Laboratory, Research Unit, Bolzano, Italy.
  • Stuppia L; University of Campus Biomedico, Dipartimento di Scienze e Tecnologie per l'uomo e l'ambiente, Rome, Italy.
  • Beccari T; Aging and Translational Medicine Research Center (CeSI-MeT), University "G. d'Annunzio", Chieti-Pescara, Italy.
Am J Med Genet B Neuropsychiatr Genet ; 183(3): 155-163, 2020 04.
Article em En | MEDLINE | ID: mdl-31746551
ABSTRACT
Evidence from family and twin studies points to a genetic contribution to the etiology of eating disorders (EDs), confirmed by the association of several single nucleotide polymorphisms (SNPs) with this group of disorders. Previous reports have suggested that the serotonin receptor (5-HT2AR) and brain-derived neurotrophic factor (BDNF) genes could be both involved in EDs susceptibility. In order to provide further evidence about such association, we focused our attention on two SNPs located in these genes carrying out a genetic association study on a large Italian cohort composed of 556 ED patients and 355 controls (CTRs). Obtained results confirm the presence of an association between 5-HT2AR and BDNF genes and the susceptibility to EDs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos da Alimentação e da Ingestão de Alimentos / Fator Neurotrófico Derivado do Encéfalo / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Receptor 5-HT2A de Serotonina Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Am J Med Genet B Neuropsychiatr Genet Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos da Alimentação e da Ingestão de Alimentos / Fator Neurotrófico Derivado do Encéfalo / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Receptor 5-HT2A de Serotonina Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Am J Med Genet B Neuropsychiatr Genet Ano de publicação: 2020 Tipo de documento: Article