miR-378a: a new emerging microRNA in metabolism.
Cell Mol Life Sci
; 77(10): 1947-1958, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-31748917
ABSTRACT
Metabolic diseases, such as type 2 diabetes or obesity, are the consequence of the disruption of the organism's metabolic pathways. The discovery of small non-coding RNAs-microRNAs (miRNAs)-as post-transcriptional gene regulators opened new doors for the development of novel strategies to combat said diseases. The two strands of miR-378a, miR-378a-3p, and miR-378a-5p are encoded in the Ppargc1b gene and have an active role in the regulation of several metabolic pathways such as mitochondrial metabolism and autophagy. Recent studies recognized miR-378a as an important regulator of energy and glucose homeostasis, highlighting it as a potential target for the improvement of metabolic dysregulation. In the present review, the current knowledge on miR-378a will be discussed with a particular emphasis on its biological functions and mechanisms of action in metabolism, mitochondria, and autophagy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
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Redes e Vias Metabólicas
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Doenças Metabólicas
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Mitocôndrias
Limite:
Humans
Idioma:
En
Revista:
Cell Mol Life Sci
Ano de publicação:
2020
Tipo de documento:
Article