Serendipitous discovery of aryl boronic acids as ß-lactamase inhibitors.
Bioorg Med Chem Lett
; 30(2): 126795, 2020 01 15.
Article
em En
| MEDLINE
| ID: mdl-31759850
ABSTRACT
High throughput screening for ß-lactamase inhibitors afforded biphenyl hits such as 1. Hit confirmation and X-ray soaking experiments with Pseudomonas Aeruginosa AmpC enzyme led to the identification of an aryl boronic acid-serine complex 4, which was formed from phenyl boronic acid 8 (an impurity in compound 1) and ethylene glycol (the cryoprotectant in the soaking experiment).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Beta-Lactamases
/
Ácidos Borônicos
/
Inibidores de beta-Lactamases
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2020
Tipo de documento:
Article