Cellular and Molecular Links between Autoimmunity and Lipid Metabolism.
Mol Cells
; 42(11): 747-754, 2019 Nov 30.
Article
em En
| MEDLINE
| ID: mdl-31766832
ABSTRACT
The incidence of atherosclerosis is higher among patients with several autoimmune diseases such as psoriasis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). It is well documented that innate immune cells including macrophages and dendritic cells sense lipid species such as saturated fatty acids and oxidized low-density lipoprotein and produce pro-inflammatory cytokines and chemokines. However, whether a hyperlipidemic environment also impacts autoimmune T cell responses has been unclear. Among CD4+ T cells, Th17 and follicular helper T (Tfh) cells are known to play pathogenic roles in the development of hyperlipidemiaassociated autoimmune diseases. This review gives an overview of the cellular and molecular mechanisms by which dysregulated lipid metabolism impacts the pathogenesis of autoimmune diseases, with specific emphasis on Th17 and Tfh cells.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Autoimunidade
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Citocinas
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Linfócitos T Auxiliares-Indutores
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Metabolismo dos Lipídeos
Limite:
Humans
Idioma:
En
Revista:
Mol Cells
Ano de publicação:
2019
Tipo de documento:
Article