Platelet-derived growth factor receptor &#945;/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients.

Leiss, Lina; Mega, Alessandro; Olsson Bontell, Thomas; Nistér, Monica; Smits, Anja; Corvigno, Sara; Rahman, Mohummad Aminur; Enger, Per Øyvind; Miletic, Hrvoje; Östman, Arne

Platelet-derived growth factor receptor α/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients.

Leiss, Lina; Mega, Alessandro; Olsson Bontell, Thomas; Nistér, Monica; Smits, Anja; Corvigno, Sara; Rahman, Mohummad Aminur; Enger, Per Øyvind; Miletic, Hrvoje; Östman, Arne.

Afiliação

Leiss L; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Mega A; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Olsson Bontell T; Department of Clinical Pathology and Cytology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Nistér M; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Acandemy, University of Gothenburg, Sweden.
Smits A; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Corvigno S; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Rahman MA; Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
Enger PØ; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Miletic H; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Östman A; Department of Biomedicine, University of Bergen, Bergen, Norway.

Glia ; 68(5): 979-988, 2020 05.

Article em En | MEDLINE | ID: mdl-31769546

Assuntos

Astrócitos/metabolismo; Neoplasias Encefálicas/mortalidade; Proteína Glial Fibrilar Ácida/metabolismo; Glioblastoma/mortalidade; Receptores do Fator de Crescimento Derivado de Plaquetas/metabolismo; Microambiente Tumoral/fisiologia; Adolescente; Adulto; Idoso; Idoso de 80 Anos ou mais; Biomarcadores Tumorais/metabolismo; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/patologia; Criança; Feminino; Proteína Glial Fibrilar Ácida/genética; Glioblastoma/genética; Glioblastoma/metabolismo; Glioblastoma/patologia; Humanos; Hibridização in Situ Fluorescente; Masculino; Pessoa de Meia-Idade; Prognóstico; Receptores do Fator de Crescimento Derivado de Plaquetas/genética; Taxa de Sobrevida; Adulto Jovem

Palavras-chave

PDGFRα; astrocyte; biomarker; cell subset; glioblastoma; tumor microenvironment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Astrócitos / Receptores do Fator de Crescimento Derivado de Plaquetas / Glioblastoma / Microambiente Tumoral / Proteína Glial Fibrilar Ácida Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Glia Ano de publicação: 2020 Tipo de documento: Article

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