Toxoplasmosis in non-cardiac solid organ transplant recipients: A case series and review of literature.
Transpl Infect Dis
; 22(1): e13218, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-31769583
ABSTRACT
The risk of toxoplasmosis in high-risk cardiac transplant recipients is well recognized prompting universal donor and candidate screening with administration of targeted post-transplant chemoprophylaxis in high-risk (D+/R-) cardiac transplant patients. In contrast, until recently, there have been neither well-defined recommendations nor consensus regarding toxoplasmosis preventive strategies among non-cardiac solid organ transplant recipients. We report 3 cases of post-transplant toxoplasmosis in non-cardiac transplant recipients (one lung and two liver); all 3 infections presumed to be donor-derived. Not surprisingly, pre-transplant Toxoplasma serology was negative in all the patients. None of the patients were on trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis at the time of diagnosis of toxoplasmosis. The median time from transplant to onset of infection was 90 days (range 30-120 days). Clinical presentations included cerebral (n = 1) and disseminated infections (n = 2). Two of the 3 patients, both with disseminated infection died (mortality ~ 67%).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
Base de dados:
MEDLINE
Assunto principal:
Doadores de Tecidos
/
Toxoplasmose
/
Transplante de Fígado
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Transplante de Pulmão
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Transplantados
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Adult
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Transpl Infect Dis
Ano de publicação:
2020
Tipo de documento:
Article