Learning and aging affect neuronal excitability and learning.
Neurobiol Learn Mem
; 167: 107133, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31786311
ABSTRACT
The first study that demonstrated a change in intrinsic neuronal excitability after learning in ex vivo brain tissue slices from a mammal was published over thirty years ago. Numerous other manuscripts describing similar learning-related changes have followed over the years since the original paper demonstrating the postburst afterhyperpolarization (AHP) reduction in CA1 pyramidal neurons from rabbits that learned delay eyeblink conditioning was published. In addition to the learning-related changes, aging-related enlargement of the postburst AHP in CA1 pyramidal neurons have been reported. Extensive work has been done relating slow afterhyperpolarization enhancement in CA1 hippocampus to slowed learning in some aging animals. These reproducible findings strongly implicate modulation of the postburst AHP as an essential cellular mechanism necessary for successful learning, at least in learning tasks that engage CA1 hippocampal pyramidal neurons.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
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Envelhecimento
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Células Piramidais
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Região CA1 Hipocampal
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Aprendizagem
Limite:
Animals
Idioma:
En
Revista:
Neurobiol Learn Mem
Ano de publicação:
2020
Tipo de documento:
Article