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A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.
Khan, Sajid; Zhang, Xuan; Lv, Dongwen; Zhang, Qi; He, Yonghan; Zhang, Peiyi; Liu, Xingui; Thummuri, Dinesh; Yuan, Yaxia; Wiegand, Janet S; Pei, Jing; Zhang, Weizhou; Sharma, Abhisheak; McCurdy, Christopher R; Kuruvilla, Vinitha M; Baran, Natalia; Ferrando, Adolfo A; Kim, Yong-Mi; Rogojina, Anna; Houghton, Peter J; Huang, Guangcun; Hromas, Robert; Konopleva, Marina; Zheng, Guangrong; Zhou, Daohong.
Afiliação
  • Khan S; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
  • Zhang X; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.
  • Lv D; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
  • Zhang Q; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • He Y; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
  • Zhang P; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.
  • Liu X; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
  • Thummuri D; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
  • Yuan Y; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
  • Wiegand JS; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
  • Pei J; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
  • Zhang W; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
  • Sharma A; Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
  • McCurdy CR; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.
  • Kuruvilla VM; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Baran N; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Ferrando AA; Department of Pediatrics, Pathology, Cell Biology and Systems of Biology and Institute for Cancer Genetics, Columbia University, New York, NY, USA.
  • Kim YM; Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA.
  • Rogojina A; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Houghton PJ; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Huang G; Department of Medicine, the Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Hromas R; Department of Medicine, the Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Konopleva M; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Zheng G; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA. zhengg@cop.ufl.edu.
  • Zhou D; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA. zhoudaohong@cop.ufl.edu.
Nat Med ; 25(12): 1938-1947, 2019 12.
Article em En | MEDLINE | ID: mdl-31792461
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Trombocitopenia / Proteína Supressora de Tumor Von Hippel-Lindau / Proteína bcl-X / Compostos de Anilina Limite: Animals / Humans Idioma: En Revista: Nat Med Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Trombocitopenia / Proteína Supressora de Tumor Von Hippel-Lindau / Proteína bcl-X / Compostos de Anilina Limite: Animals / Humans Idioma: En Revista: Nat Med Ano de publicação: 2019 Tipo de documento: Article