Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.

Mórotz, Gábor M; Glennon, Elizabeth B; Greig, Jenny; Lau, Dawn H W; Bhembre, Nishita; Mattedi, Francesca; Muschalik, Nadine; Noble, Wendy; Vagnoni, Alessio; Miller, Christopher C J

Mórotz, Gábor M; Glennon, Elizabeth B; Greig, Jenny; Lau, Dawn H W; Bhembre, Nishita; Mattedi, Francesca; Muschalik, Nadine; Noble, Wendy; Vagnoni, Alessio; Miller, Christopher C J.

Afiliação

Mórotz GM; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane Camberwell, London, SE5 9RX, UK.
Glennon EB; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane Camberwell, London, SE5 9RX, UK.
Greig J; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane Camberwell, London, SE5 9RX, UK.
Lau DHW; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane Camberwell, London, SE5 9RX, UK.
Bhembre N; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane Camberwell, London, SE5 9RX, UK.
Mattedi F; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane Camberwell, London, SE5 9RX, UK.
Muschalik N; Division of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
Noble W; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane Camberwell, London, SE5 9RX, UK.
Vagnoni A; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane Camberwell, London, SE5 9RX, UK. alessio.vagnoni@kcl.ac.uk.
Miller CCJ; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane Camberwell, London, SE5 9RX, UK. chris.miller@kcl.ac.uk.

Acta Neuropathol Commun ; 7(1): 200, 2019 12 05.

Article em En | MEDLINE | ID: mdl-31806024

Assuntos

Doença de Alzheimer/metabolismo; Precursor de Proteína beta-Amiloide/biossíntese; Transporte Axonal/fisiologia; Proteínas Associadas aos Microtúbulos/metabolismo; Serina/metabolismo; Idoso; Idoso de 80 Anos ou mais; Doença de Alzheimer/genética; Doença de Alzheimer/patologia; Sequência de Aminoácidos; Precursor de Proteína beta-Amiloide/análise; Precursor de Proteína beta-Amiloide/genética; Animais; Proteínas de Drosophila; Drosophila melanogaster; Feminino; Lobo Frontal/química; Lobo Frontal/metabolismo; Lobo Frontal/patologia; Células HEK293; Humanos; Cinesinas; Masculino; Proteínas Associadas aos Microtúbulos/análise; Proteínas Associadas aos Microtúbulos/genética; Fosforilação/fisiologia; Ratos; Serina/análise; Serina/genética

Palavras-chave

Alzheimer's disease; Amyloid precursor protein; Axonal transport; Calsyntenin-1; Drosophila melanogaster; Kinesin light chain; Kinesin-1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Serina / Transporte Axonal / Precursor de Proteína beta-Amiloide / Doença de Alzheimer / Proteínas Associadas aos Microtúbulos Limite: Aged / Aged80 / Animals / Female / Humans / Male Idioma: En Revista: Acta Neuropathol Commun Ano de publicação: 2019 Tipo de documento: Article

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