In case of recurrent wheezing and bronchiolitis: Think again, it may be a primary immunodeficiency.
Asian Pac J Allergy Immunol
; 40(4): 442-446, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-31837214
ABSTRACT
BACKGROUND:
Wheezing, starting early in life, is a heterogeneous medical condition caused by airway obstruction due to different underlying mechanisms. Primary immunodeficiencies are also among the risk factors that cause wheezing and recurrent bronchiolitis. ADA deficiency is a primary immunodeficiency, also a rare metabolic disease associated with multisystemic clinical findings.OBJECTIVE:
This report will be helpful for adressing the importance of thinking primary immunodeficiency in case of wheezing and recurret bronchiolitis.METHODS:
The patient was diagnosed by using a targeted next generation sequencing PID panel. Lymphocyte subsets were measured by flow-cytometry.RESULTS:
Here we present an infant with ADA deficiency who admitted with wheezing and recurrent bronchiolitis as the first presentation. He was found to have wheezing, relative CD4+ T cell deficiency, and prolonged neutropenia.CONCLUSIONS:
Primary immunodeficiencies including ADA deficiency should be considered in infants with wheezing, recurrent bronchiolitis, lymphopenia and neutropenia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bronquiolite
/
Agamaglobulinemia
/
Neutropenia
Limite:
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
2022
Tipo de documento:
Article