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Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue.
Sternby, Hanna; Mahle, Mariella; Linder, Nicolas; Erichson-Kirst, Laureen; Verdonk, Robert C; Dimova, Alexandra; Ignatavicius, Povilas; Ilzarbe, Lucas; Koiva, Peeter; Penttilä, Anne; Regnér, Sara; Bollen, Thomas L; Brill, Richard; Stangl, Franz; Wohlgemuth, Walter A; Singh, Vijay; Busse, Harald; Michl, Patrick; Beer, Sebastian; Rosendahl, Jonas.
Afiliação
  • Sternby H; Department of Surgery, Institution of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
  • Mahle M; Department of Internal Medicine I, Martin Luther University, Halle (Saale), Germany.
  • Linder N; Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.
  • Erichson-Kirst L; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
  • Verdonk RC; Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, Leipzig, Germany.
  • Dimova A; Department of Gastroenterology, St. Antonius Ziekenhuis, Nieuwegein, the Netherlands.
  • Ignatavicius P; Department of Surgery, University Hospital for Emergency Medicine "Pirogov", Sofia, Bulgaria.
  • Ilzarbe L; Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Koiva P; Department of Gastroenterology, Hospital del Mar, Barcelona, Spain.
  • Penttilä A; Department of Gastroenterology, East Tallinn Central Hospital, Tallinn, Estonia.
  • Regnér S; Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland.
  • Bollen TL; Department of Surgery, Institution of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
  • Brill R; Department of Radiology, St. Antonius Ziekenhuis, Nieuwegein, the Netherlands.
  • Stangl F; Department of Radiology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
  • Wohlgemuth WA; Department of Radiology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
  • Singh V; Department of Radiology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
  • Busse H; Department of Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
  • Michl P; Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.
  • Beer S; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
  • Rosendahl J; Department of Internal Medicine I, Martin Luther University, Halle (Saale), Germany.
United European Gastroenterol J ; 7(10): 1312-1320, 2019 12.
Article em En | MEDLINE | ID: mdl-31839956
Background: Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. Objective: The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP. Methods: In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves. Results: No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with p-values of 0.037 and 0.003 respectively. In multivariate analysis, low muscle attenuation was associated with severe AP with an odds ratio of 4.09 (95% confidence intervals: 1.61-10.36, p-value 0.003). No body parameter presented sufficient predictive capability in ROC-curve analysis. Conclusions: Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pancreatite / Gordura Intra-Abdominal / Gordura Subcutânea / Músculos Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: United European Gastroenterol J Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pancreatite / Gordura Intra-Abdominal / Gordura Subcutânea / Músculos Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: United European Gastroenterol J Ano de publicação: 2019 Tipo de documento: Article