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Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain.
Graves, Steven M; Xie, Zhong; Stout, Kristen A; Zampese, Enrico; Burbulla, Lena F; Shih, Jean C; Kondapalli, Jyothisri; Patriarchi, Tommaso; Tian, Lin; Brichta, Lars; Greengard, Paul; Krainc, Dimitri; Schumacker, Paul T; Surmeier, D James.
Afiliação
  • Graves SM; Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Xie Z; Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Stout KA; Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Zampese E; Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Burbulla LF; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Shih JC; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA.
  • Kondapalli J; Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Patriarchi T; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California-Davis Davis, Davis, CA, USA.
  • Tian L; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California-Davis Davis, Davis, CA, USA.
  • Brichta L; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA.
  • Greengard P; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA.
  • Krainc D; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Schumacker PT; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Surmeier DJ; Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. j-surmeier@northwestern.edu.
Nat Neurosci ; 23(1): 15-20, 2020 01.
Article em En | MEDLINE | ID: mdl-31844313
ABSTRACT
Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2). We show that MAO metabolism of DA does not increase cytosolic H2O2 but leads to mitochondrial electron transport chain (ETC) activity. This is dependent upon MAO anchoring to the outer mitochondrial membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Transporte de Elétrons / Metabolismo Energético / Neurônios Dopaminérgicos / Monoaminoxidase Limite: Animals / Humans / Male Idioma: En Revista: Nat Neurosci Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Transporte de Elétrons / Metabolismo Energético / Neurônios Dopaminérgicos / Monoaminoxidase Limite: Animals / Humans / Male Idioma: En Revista: Nat Neurosci Ano de publicação: 2020 Tipo de documento: Article