Overview of the relevance of PI3K pathway in HR-positive breast cancer.
Ann Oncol
; 30(Suppl_10): x3-x11, 2019 12 01.
Article
em En
| MEDLINE
| ID: mdl-31859348
ABSTRACT
One of the hallmarks of hormone receptor (HR)-positive breast cancer is its dependence on the phosphatidylinositol-3-kinase (PI3K) pathway. Here, we review the epidemiologic, functional, and pharmacologic interactions between oncogenic PI3K and the estrogen receptor (ER). We discuss the epidemiology of PI3K pathway alterations, mechanisms of resistance to PI3K inhibitors, and the current mechanistic landscape of crosstalk between PI3K and ER, which provide the rationale for dual ER and PI3K inhibition and is now a standard of care in the treatment of ER+ PIK3CA-mutant metastatic breast cancer. We outline newer studies in this field that delineate the clinically relevant overlaps between PI3K and parallel signaling pathways, insulin signaling, and ER epigenetic modifiers. We also identify several caveats with the current data and propose new strategies to overcome these bottlenecks.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Receptores de Estrogênio
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Fosfatidilinositol 3-Quinases
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Ann Oncol
Ano de publicação:
2019
Tipo de documento:
Article