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12q14 microduplication: a new clinical entity reciprocal to the microdeletion syndrome?
Dória, Sofia; Alves, Daniela; Pinho, Maria João; Pinto, Joel; Leão, Miguel.
Afiliação
  • Dória S; Genetics Service, Department of Pathology, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200, Porto, Portugal. sdoria@med.up.pt.
  • Alves D; Instituto de Investigação e Inovação em Saúde - i3S, Universidade do Porto, Porto, Portugal. sdoria@med.up.pt.
  • Pinho MJ; Department of Pediatrics, São João Hospital Centre - CHSJ, Porto, Portugal.
  • Pinto J; Genetics Service, Department of Pathology, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200, Porto, Portugal.
  • Leão M; Instituto de Investigação e Inovação em Saúde - i3S, Universidade do Porto, Porto, Portugal.
BMC Med Genomics ; 13(1): 2, 2020 01 03.
Article em En | MEDLINE | ID: mdl-31900140
BACKGROUND: 12q14 microdeletion syndrome is characterized by low birth weight and failure to thrive, proportionate short stature and developmental delay. The opposite syndrome (microduplication) has not yet been characterized. Our main objective is the recognition of a new clinical entity - 12q14 microduplication syndrome. - as well as confirming the role of HMGA2 gene in growth regulation. CASE PRESENTATION: Array Comparative Genomic Hybridization (CGH), Karyotype, Fluorescence in situ Hybridization, Quantitative-PCR analysis and Whole exome sequencing (WES) were performed in a girl presenting overgrowth and obesity. Array CGH identified a 1.5 Mb 12q14.3 microduplication involving HMGA2, GRIP1, IRAK3, MSRB3 and TMBIM4 genes. Karyotype and FISH showed that duplication was a de novo insertion of 12q14.3 region on chromosome 9p resulting in an interstitial microduplication. Q-PCR confirmed the duplication only in the proband. WES revealed no pathogenic variants. CONCLUSIONS: Phenotypic comparison with patients with 12q14 microdeletion syndrome showed a reciprocal presentation, suggesting a phenotypically recognizable 12q14 microduplication syndrome as well as confirming the role of HMGA2 gene in growth regulation. It is also indicative that other genes, such as IRAK3 and MSRB3 might have of role in weight gain and obesity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Par 9 / Cromossomos Humanos Par 12 / Deficiências do Desenvolvimento / Deleção Cromossômica / Duplicação Cromossômica Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: BMC Med Genomics Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Par 9 / Cromossomos Humanos Par 12 / Deficiências do Desenvolvimento / Deleção Cromossômica / Duplicação Cromossômica Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: BMC Med Genomics Ano de publicação: 2020 Tipo de documento: Article