NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug.
Chem Commun (Camb)
; 56(9): 1397-1400, 2020 Jan 30.
Article
em En
| MEDLINE
| ID: mdl-31912815
NAMI-A is highly reactive to Sp1, a tumor metastasis related protein, resulting in the perturbation of the protein structure and disruption of the DNA recognition of Sp1. Interestingly, Sp1 is more susceptible than other zinc finger proteins to NAMI-A, suggesting that Sp1 could be the anti-metastasis target of NAMI-A.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Dimetil Sulfóxido
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Fator de Transcrição Sp1
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Compostos de Rutênio
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Antineoplásicos
Idioma:
En
Revista:
Chem Commun (Camb)
Ano de publicação:
2020
Tipo de documento:
Article