Design and synthesis of &#945;-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation.

Zhou, Li; Chen, Wenming; Cao, Chenyang; Shi, Yonghui; Ye, Wenchong; Hu, Jiliang; Wang, LingLi; Zhou, Wen

Design and synthesis of α-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation.

Zhou, Li; Chen, Wenming; Cao, Chenyang; Shi, Yonghui; Ye, Wenchong; Hu, Jiliang; Wang, LingLi; Zhou, Wen.

Afiliação

Zhou L; College of Science, Hunan Agricultural University, Furong Rd, Changsha, 410128, China.
Chen W; Department of Pharmaceutical Production Center, The First Affiliated Hospital of Hunan University of Chinese Medicine, 95, Shaoshan Rd, Changsha, Hunan, 41007, China.
Cao C; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, E. 232, University Town, Waihuan Rd, Panyu, Guangzhou, 510006, China.
Shi Y; Department of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, Guangdong, China.
Ye W; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, E. 232, University Town, Waihuan Rd, Panyu, Guangzhou, 510006, China.
Hu J; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, E. 232, University Town, Waihuan Rd, Panyu, Guangzhou, 510006, China.
Wang L; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, E. 232, University Town, Waihuan Rd, Panyu, Guangzhou, 510006, China. Electronic address: wanglingli@126.com.
Zhou W; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, E. 232, University Town, Waihuan Rd, Panyu, Guangzhou, 510006, China. Electronic address: zhouwen60@126.com.

Eur J Med Chem ; 189: 112028, 2020 Mar 01.

Article em En | MEDLINE | ID: mdl-31945665

Assuntos

Benzoflavonas/farmacologia; Citocromo P-450 CYP1B1/antagonistas & inibidores; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Talidomida/análogos & derivados; Talidomida/farmacologia; Benzoflavonas/síntese química; Linhagem Celular Tumoral; Citocromo P-450 CYP1B1/metabolismo; Docetaxel/farmacologia; Desenho de Fármacos; Humanos; Proteólise; Talidomida/síntese química

Palavras-chave

CYP1B1; Click reaction; PROTACs; Reversal of drug resistance; α-Naphthoflavone-based conjugates

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talidomida / Benzoflavonas / Resistencia a Medicamentos Antineoplásicos / Citocromo P-450 CYP1B1 Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2020 Tipo de documento: Article

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