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A novel water-soluble quinoline-indole derivative as a three-photon fluorescent probe for identifying nucleolus RNA and mitochondrial DNA.
Elhussin, Imad Elddin Haj; Zhang, Sijing; Liu, Jiejie; Li, Dandan; Zhang, Qiong; Li, Shengli; Tian, Xiaohe; Wu, Jieying; Tian, Yupeng.
Afiliação
  • Elhussin IEH; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, P. R. China. zhangqiong.314@163.com yptian@ahu.edu.cn.
  • Zhang S; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, P. R. China. zhangqiong.314@163.com yptian@ahu.edu.cn.
  • Liu J; School of Life Science, Anhui University, Hefei 230039, P. R. China.
  • Li D; Institutes of Physics Science and Information Technology, Anhui University, Hefei 230039, P. R. China.
  • Zhang Q; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, P. R. China. zhangqiong.314@163.com yptian@ahu.edu.cn.
  • Li S; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, P. R. China. zhangqiong.314@163.com yptian@ahu.edu.cn.
  • Tian X; School of Life Science, Anhui University, Hefei 230039, P. R. China.
  • Wu J; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, P. R. China. zhangqiong.314@163.com yptian@ahu.edu.cn.
  • Tian Y; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, P. R. China. zhangqiong.314@163.com yptian@ahu.edu.cn.
Chem Commun (Camb) ; 56(12): 1859-1862, 2020 Feb 11.
Article em En | MEDLINE | ID: mdl-31950954
ABSTRACT
We present the design and synthesis of water-soluble quinoline-indole-based derivatives (IM-1, IM-2, and IM-3) with three-photon absorption activity. IM-3 can specifically target DNA and RNA accompanied by an obvious three-photon fluorescence enhancement in the second near-infrared window (1000-1700 nm). The in vitro experiments demonstrate that IM-3 can simultaneously stain mitochondria and the nucleolus both in living and fixed cells. The organelle-specific targeting behaviour is successfully visualized under stimulated emission depletion (STED) nanoscopy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / DNA Mitocondrial / RNA Neoplásico / Fótons / Corantes Fluorescentes / Indóis Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / DNA Mitocondrial / RNA Neoplásico / Fótons / Corantes Fluorescentes / Indóis Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2020 Tipo de documento: Article