Isocadiolides A-H: Polybrominated Aromatics from a Synoicum sp. Ascidian.
J Nat Prod
; 83(2): 429-437, 2020 02 28.
Article
em En
| MEDLINE
| ID: mdl-31967465
ABSTRACT
Isocadiolides A-H (1-8) and cadiolide N (9), new polybrominated aromatic compounds, were isolated from a Korean Synoicum sp. ascidian. On the basis of the results of extensive spectroscopic analyses, these compounds possessed tris-bromohydroxyphenyl moieties as a common structural motif, while their cores varied [cyclopentenedione (1-5), dihydrofuran (6 and 7), pyranone (8), and furanone (9)], reflecting different extents of rearrangement and oxidation. Several of these compounds exhibited weak antibacterial activities and moderate abilities to inhibit the microbial enzymes sortase A and isocitrate lyase.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
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Urocordados
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Cisteína Endopeptidases
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Bifenil Polibromatos
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Aminoaciltransferases
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Isocitrato Liase
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Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2020
Tipo de documento:
Article