Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity.

Mohammed, Sabira; Vineetha, Nalanda S; James, Shirley; Aparna, Jayasekharan S; Babu Lankadasari, Manendra; Maeda, Takahiro; Ghosh, Abhirupa; Saha, Sudipto; Li, Quan-Zhen; Spiegel, Sarah; Harikumar, Kuzhuvelil B

Mohammed, Sabira; Vineetha, Nalanda S; James, Shirley; Aparna, Jayasekharan S; Babu Lankadasari, Manendra; Maeda, Takahiro; Ghosh, Abhirupa; Saha, Sudipto; Li, Quan-Zhen; Spiegel, Sarah; Harikumar, Kuzhuvelil B.

Afiliação

Mohammed S; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, India.
Vineetha NS; Manipal Academy of Higher Education (MAHE), Manipal, India.
James S; Department of Nephrology, Government Medical College, Thiruvananthapuram, India.
Aparna JS; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, India.
Babu Lankadasari M; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, India.
Maeda T; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, India.
Ghosh A; Manipal Academy of Higher Education (MAHE), Manipal, India.
Saha S; Department of Island and Community Medicine, Island Medical Research Institute, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Li QZ; Bioinformatics Center, Bose Institute, Kolkata, India.
Spiegel S; Bioinformatics Center, Bose Institute, Kolkata, India.
Harikumar KB; Department of Immunology & Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

FASEB J ; 34(3): 4329-4347, 2020 03.

Article em En | MEDLINE | ID: mdl-31971297

Assuntos

Autoimunidade/fisiologia; Interferon Tipo I/metabolismo; Receptor 7 Toll-Like/metabolismo; Receptor Toll-Like 9/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/genética; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Animais; Autoimunidade/genética; Western Blotting; Células HEK293; Humanos; Fator Regulador 3 de Interferon/genética; Fator Regulador 3 de Interferon/metabolismo; Fator Regulador 7 de Interferon/genética; Fator Regulador 7 de Interferon/metabolismo; Interferon Tipo I/genética; Camundongos; Camundongos Endogâmicos C57BL; Modelos Biológicos; Receptor 7 Toll-Like/genética; Receptor Toll-Like 9/genética

Palavras-chave

auto-immunity; interferon; plasmacytoid dendritic cells; sphingosine 1-Phosphate; sphingosine kinase; systemic lupus erythematosus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon Tipo I / Autoimunidade / Receptor Toll-Like 9 / Receptor 7 Toll-Like Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: FASEB J Ano de publicação: 2020 Tipo de documento: Article

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