Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles.
Cytokine Growth Factor Rev
; 51: 92-98, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31973992
ABSTRACT
A small group of mucosal Human Papillomaviruses are the causative agents of cervical cancer and are also associated with other types of cancers. Certain cutaneous Human Papillomaviruses seem to have a role as co-factors in the UV-induced carcinogenesis of the skin. The main mechanism of the tumorigenesis induced by Human Papillomaviruses is linked to the transforming activity of the viral E6 and E7 oncoproteins. However, other mechanisms, such as the gene expression control by specific microRNAs expression and deregulation of immune inflammatory mediators, may be important in the process of transformation. In this context, the release of Extracellular Vesicles with a specific cargo (microRNAs involved in tumorigenesis, mRNAs of viral oncoproteins, cytokines, chemokines) appears to play a key role.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Comunicação Celular
/
Infecções por Papillomavirus
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Alphapapillomavirus
/
Carcinogênese
/
Vesículas Extracelulares
Limite:
Female
/
Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Ano de publicação:
2020
Tipo de documento:
Article