Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy.

Bue, Mats; Sou, Tomás; Okkels, Anna Sophie L; Hanberg, Pelle; Thorsted, Anders; Friberg, Lena E; Andersson, Torben L; Öbrink-Hansen, Kristina; Christensen, Steffen

Bue, Mats; Sou, Tomás; Okkels, Anna Sophie L; Hanberg, Pelle; Thorsted, Anders; Friberg, Lena E; Andersson, Torben L; Öbrink-Hansen, Kristina; Christensen, Steffen.

Afiliação

Bue M; Department of Orthopaedic Surgery, Horsens Regional Hospital, Sundvej 30, 8700 Horsens, Denmark; Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark; Orthopaedic Research Unit, Aarhus University Hospital, Palle Ju
Sou T; Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24 Uppsala, Sweden. Electronic address: tomas.sou@farmaci.uu.se.
Okkels ASL; Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: asokkels@hotmail.com.
Hanberg P; Department of Orthopaedic Surgery, Horsens Regional Hospital, Sundvej 30, 8700 Horsens, Denmark; Orthopaedic Research Unit, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: pehanb@rm.dk.
Thorsted A; Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24 Uppsala, Sweden. Electronic address: anders.thorsted@farmbio.uu.se.
Friberg LE; Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24 Uppsala, Sweden. Electronic address: lena.friberg@farmbio.uu.se.
Andersson TL; Department of Clinical Biochemistry, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: t.l.a@stofanet.dk.
Öbrink-Hansen K; Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: kristina.Obrink.Hansen@auh.rm.dk.
Christensen S; Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: steffen.christensen@auh.rm.dk.

Int J Infect Dis ; 92: 133-140, 2020 Mar.

Article em En | MEDLINE | ID: mdl-31978581

Assuntos

Antibacterianos/farmacocinética; Infecções Bacterianas/tratamento farmacológico; Terapia de Substituição Renal Contínua; Combinação Piperacilina e Tazobactam/farmacocinética; Tela Subcutânea/metabolismo; Idoso; Idoso de 80 Anos ou mais; Antibacterianos/uso terapêutico; Infecções Bacterianas/microbiologia; Simulação por Computador; Feminino; Humanos; Masculino; Modelos Biológicos; Combinação Piperacilina e Tazobactam/sangue; Combinação Piperacilina e Tazobactam/uso terapêutico; Estudos Prospectivos; Infecções por Pseudomonas/tratamento farmacológico; Pseudomonas aeruginosa/efeitos dos fármacos

Palavras-chave

Continuous renal replacement therapy; Microdialysis; Modelling; PK/PD; Tissue distribution; ß-lactams

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Bacterianas / Tela Subcutânea / Combinação Piperacilina e Tazobactam / Terapia de Substituição Renal Contínua / Antibacterianos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Int J Infect Dis Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google