Association between SNPs and Loss of Methylation Site on the CpG island of the Promoter Region of the Smoothened Gene, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population.
Asian Pac J Cancer Prev
; 21(1): 25-29, 2020 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-31983159
ABSTRACT
OBJECTIVE:
Perform genotyping of SNPs in the promoter region of the SMO gene in BCC samples from patients from northeastern Brazil, and to determine if there is an association of these SNPs of the gene in question with the susceptibility to the development of the BCC.METHODS:
100 samples of paraffined tissue from patients with histopathological diagnosis of BCC and 100 control samples were analyzed for each polymorphism by a newly developed genotyping method, the Dideoxy Single Allele Specific - PCR. The software Bioestat - version 5.3 and Haploview 4.2 were used for the statistical analysis. For all tests a P-value.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Carcinoma Basocelular
/
Regiões Promotoras Genéticas
/
Ilhas de CpG
/
Metilação de DNA
/
Polimorfismo de Nucleotídeo Único
/
Receptor Smoothened
Tipo de estudo:
Observational_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Asian Pac J Cancer Prev
Ano de publicação:
2020
Tipo de documento:
Article